Evaluation Of C-Reactive Protein In Urinary Tract Infected Patients Attending Madonna University Teaching Hospital

Authors

  • Johnkennedy Nnodim IMO STATE UNIVERSITY, OWERRI

DOI:

https://doi.org/10.37899/mjdh.v2i1.159

Keywords:

C-Reactive Protein, Urinary Tract, Infected Patients

Abstract

This study was carried out to determine the level of C-reactive protein (CRP) in Urinary Tract infection Patients attending Madonna University Teaching Hospital. C- reactive protein was measured using the ELISA (Enzyme-Linked Immunosorbent Assay) method. The statistical software for social sciences (SPSS) version 26 was used to statistically analyze the data acquired from this study. C- reactive protein values in the UTI group (20.75±8.35 mg/L) were significantly higher than those in the control group (3.08±1.28 mg/L), demonstrating a strong inflammatory response to UTIs. Additionally, age-related study showed that children and adolescents had greater CRP levels than adults. Patients with Escherichia coli showed considerably higher CRP levels than Klebsiella pneumoniae and Proteus mirabilis in the bacterial growth categories, however no significant difference was seen between Klebsiella pneumoniae and Proteus mirabilis. Differences in immune response dynamics, pathogen pathogenicity, and host-pathogen interactions can be used to explain these variances in CRP levels. The results show how useful CRP is as an inflammatory marker in UTIs.

References

Bajic, G., Degn, S. E., Thiel, S., & Andersen, G. R. (2015). Complement activation, regulation, and molecular basis for complement‐related diseases. The EMBO journal, 34(22), 2735-2757. https://doi.org/10.15252/embj.201591881

Byron, J. K. (2019). Urinary tract infection. The Veterinary Clinics of North America. Small Animal Practice, 49(2), 211–221. https://doi.org/10.1016/j.cvsm.2018.12.008

Carbo, J. F., Ruh, C. A., Kurtzhalts, K. E., Ott, M. C., Sellick, J. A., & Mergenhagen, K. A. (2016). Male veterans with complicated urinary tract infections: Influence of a patient-centered antimicrobial stewardship program. American Journal of Infection Control, 44(12), 1549-1553. https://doi.org/10.1016/j.ajic.2016.06.020

Charles, M., Clyne, B., & Olshaker, J. S. (1974). The C-reactive protein. Journal of Emergency Medicine, 17(6), 1019–1025. https://doi.org/10.1016/0736-4679(74)90363-3

Chaudhari, P. P., Monuteaux, M. C., & Bachur, R. G. (2018). Microscopic bacteriuria detected by automated urinalysis for the diagnosis of urinary tract infection. The Journal of Pediatrics, 202, 238-244. https://doi.org/10.1016/j.jpeds.2018.06.018

Chu, C. M., & Lowder, J. L. (2018). Diagnosis and treatment of urinary tract infections across age groups. American Journal of Obstetrics and Gynecology, 219(1), 40–51. https://doi.org/10.1016/j.ajog.2018.02.030

Geerlings, S. E. (2017). Clinical presentations and epidemiology of urinary tract infections. In Urinary Tract Infections: Molecular Pathogenesis and Clinical Management (pp. 27-40).

Guerreiro, V. A., Carvalho, D., & Freitas, P. (2022). Obesity, adipose tissue, and inflammation answered in questions. Journal of obesity, 2022(1), 2252516. https://doi.org/10.1155/2022/2252516

Gupta, K., Grigoryan, L., & Trautner, B. (2017). Urinary tract infection. Annals of Internal Medicine, 167(7), ITC49–ITC64. https://doi.org/10.7326/AITC201710030

Hickling, D. R., Sun, T. T., & Wu, X. R. (2017). Anatomy and physiology of the urinary tract: Relation to host defense and microbial infection. In Urinary Tract Infections: Molecular Pathogenesis and Clinical Management (pp. 1-25). https://doi.org/10.1128/microbiolspec.uti-0016-2012

Jarczak, D., & Nierhaus, A. (2022). Cytokine storm—definition, causes, and implications. International journal of molecular sciences, 23(19), 11740. https://doi.org/10.3390/ijms231911740

Jhang, J. F., & Kuo, H. C. (2017). Recent advances in recurrent urinary tract infection from pathogenesis and biomarkers to prevention. Tzu-Chi Medical Journal, 29(3), 131. https://doi.org/10.4103/tcmj.tcmj_124_17

Jung, C., & Brubaker, L. (2019). The etiology and management of recurrent urinary tract infections in postmenopausal women. Climacteric, 22(3), 242-249. https://doi.org/10.1080/13697137.2019.1570247

Keren, R., Shaikh, N., Pohl, H., Gravens-Mueller, L., Ivanova, A., Zaoutis, L., & Hoberman, A. (2015). Risk factors for recurrent urinary tract infection and renal scarring. Pediatrics, 136(1), e13-e21. https://doi.org/10.1542/peds.2015-0334

Kline, K. A., & Lewis, A. L. (2017). Gram-positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract. In Urinary Tract Infections: Molecular Pathogenesis and Clinical Management (pp. 459-502).

Li, D., & Wu, M. (2021). Pattern recognition receptors in health and diseases. Signal transduction and targeted therapy, 6(1), 291. https://doi.org/10.1038/s41392-021-00687-0

Litvack, M. L., & Palaniyar, N. (2010). Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation. Innate immunity, 16(3), 191-200. https://doi.org/10.1177/1753425910369271

Luo, Y., & Lin, H. (2021). Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease. Immunity, Inflammation and Disease, 9(1), 59-73. https://doi.org/10.1002/iid3.391

McLellan, L. K., & Hunstad, D. A. (2016). Urinary tract infection: Pathogenesis and outlook. Trends in Molecular Medicine, 22(11), 946–957. https://doi.org/10.1016/j.molmed.2016.09.003

Medina, M., & Castillo-Pino, E. (2019). An introduction to the epidemiology and burden of urinary tract infections. Therapeutic Advances in Urology, 11, 175. https://doi.org/10.1177/1756287219853637

Nayak, A., Pednekar, L., Reid, K. B., & Kishore, U. (2012). Complement and non-complement activating functions of C1q: a prototypical innate immune molecule. Innate immunity, 18(2), 350-363. https://doi.org/10.1177/1753425910396252

Pope, J. E., & Choy, E. H. (2021). C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Seminars in Arthritis and Rheumatism, 51(1), 219-229. https://doi.org/10.1016/j.semarthrit.2020.08.013

Sheriff, A., Kayser, S., Brunner, P., & Vogt, B. (2021). C-reactive protein triggers cell death in ischemic cells. Frontiers in Immunology, 12, 630430. https://doi.org/10.3389/fimmu.2021.630430

Skow, M. A., Vik, I., & Høye, S. (2020). Antibiotic switch after treatment with UTI antibiotics in male patients. Infectious Diseases, 52(6), 405-412. https://doi.org/10.1080/23744235.2020.1790500

Stanimirovic, J., Radovanovic, J., Banjac, K., Obradovic, M., Essack, M., Zafirovic, S., ... & Isenovic, E. R. (2022). Role of C‐reactive protein in diabetic inflammation. Mediators of inflammation, 2022(1), 3706508. https://doi.org/10.1155/2022/3706508

Tenke, P., Köves, B., & Johansen, T. E. (2014). An update on prevention and treatment of catheter-associated urinary tract infections. Current Opinion in Infectious Diseases, 27(1), 102-107. https://doi.org/10.1097/QCO.0000000000000020

Torre, M., Furrow, E., & Foster, J. D. (2022). Effect of urine-specific gravity on performance of bacteriuria in predicting urine culture results. Journal of Small Animal Practice, 63(4), 286-292. https://doi.org/10.1111/jsap.13395

Usman, M. W., & Syed, S. R. (2018). Background evidence to demonstrate the prevalence. Journal of Applications in the Atmospheric Sciences, 32(14), 2627-2636. https://doi.org/10.1175/JAS-D-18-0114.1

Wimalawansa, S. J. (2023). Infections and autoimmunity—the immune system and vitamin D: a systematic review. Nutrients, 15(17), 3842. https://doi.org/10.3390/nu15173842

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Published

2025-03-09